RESISTANCE OF CONDITIONALLY PATHOGENIC MICROORGANISMS ISOLATED FROM CATS AND DOGS WITH GASTROINTESTINAL DISEASES TO ANTIMICROBIAL DRUGS

Abstract

Resistance to antibacterial drugs is widespread among microorganisms that cause infectious diseases, as well as conditionally pathogenic microorganisms. Diseases caused, as well as complicated, by strains of bacteria resistant to antimicrobial drugs are characterized by a long course and worsen the further prognosis of the disease. The aim of the study was to isolate conditionally pathogenic enterobacteria in gastrointestinal diseases in cats and dogs, with the determination of phenotypic and genotypic resistance to antimicrobial drugs. The object of the research was biological material from small domestic animals with clinical manifestations of diseases of the gastrointestinal tract, taken in veterinary clinics of Kostanay. A total of 108 samples were examined. 57 microorganisms were isolated and identified from biological material: E.coli (n=33), Klebsiella (n=6), Citrobacter (n=5), Enterobacter (n=7), Proteus (n=6). The spectrum of determining the sensitivity of microorganisms was 21 antibiotics of various pharmacological groups. As a result of the conducted studies, all 57 isolates of enterobacteria were polyresistant. The strains showed the greatest resistance to antibacterial drugs of the tetracycline and beta-lactam group, while they showed sensitivity to the action of meropenem, strepatomycin and gentamicin. A large number of microorganisms have genes encoding resistance to beta-lactams (n=16) and aminoglycosides (n=28).

Scientific research was carried out within the framework of the AP09058122 project "Prevalence of determinants of resistance to antibacterial drugs" grant funding of the Ministry of Education and Science of the Republic of Kazakhstan for 2021-2023.