ALLELIC POLYMORPHISM OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVE TRAITS OF SHEEP OF THE KAZAKH FAT-TAILED BREED

Abstract

In recent years, research aimed at developing breeding methods based on the use of DNA markers associated with the level of productivity has become particularly important. The introduction of this technology into the domestic production of mutton is on urgent task of great practical importance for the development of this industry. In this regard, the goal was set to study the polymorphism of the alleles of growth hormone (GH2), insulin-like growth factor (IGF1), myostatin (MSTN), and fatty acid binding protein-4 (FABP4) genes associated with the productivity of Kazakh fat-tailed sheep.

Blood samples were used to study animal DNA. The analysis of polymorphism in genes was carried out with the help of test systems that were specially designed to carry out research work in the laboratory of Molecular Bases of Breeding of the All-Russian institute of Animal Husbandry named after L.K. Ernst (Russia).

During the study of polymorphic sistems of blood proteins, the degree of differentiation of the genetic structures of the Kazakh fat-tailed breed by alleles and genotypes of polymorphic proteins was determined. As a result of testing, it was revealed that in the population of Kazakh fat-tailed sheep, the GH2 and IGF1 genes are polymorphic and the MSTN and FABP4 genes are monomorphic.

Identification of candidate genes associated with signs of meat productivity of the Kazakh fat-tailed breed can be used to develop marker breeding programs, the use of which in practice can significantly improve the efficiency of breeding work.