ETHIOPATHOGENETIC CHANGES IN THE BLOOD OF CATTLE CAUSED BY LEPTOSPIROSIS

Abstract

This paper presents the results of a study of the clinical picture, pathoanatomical changes, morphological and biochemical blood parameters in cattle with leptospirosis.It was established that the disease is characterized by the development of anemia and a chronic inflammatory process and is accompanied by a decrease in the level of hemoglobin in animals to 120.6±5.4 g/l, erythrocytes to 4.61±0.39 million/μl, and an increase in the erythrocyte sedimentation rate to 2 .5-4.0 mm/h From the biochemical parameters there was a decrease in total protein which was 70,5±1,1 g/l, an increase in ALT and AST to 98,59±3,2 and 167,75±8,8 units/l respectively, an increase in total bilirubin 21,95±1,08 μmol/l, as well as an increase in creatinine to 142,21±8,3 μmol/l and urea to 21,71±0,33 mmol/l. The results obtained confirm the previous data of scientists who have described in their articles the pathological processes occurring in leptospirosis An increase in liver enzymes is probably related to the release of hemolytic toxins by leptospira, and an increase in bilirubin levels indicates damage to the bile ducts. Such changes are a consequence of the development in the body of a sick animal of etiopathogenesis caused by pathogenicity factors of leptospira and cause a specific pathological and anatomical picture for this disease, characterized by anemia, hemoglobinuria and yellowness of the mucous membranes and skin.